Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/314409912?client_source=feed&format=rss
actuary elon musk fox mole manson bubba watson recent earthquakes fbi most wanted list
Saturday, June 22, 2013
Potential drug compound attacks Parkinson's on two fronts
June 20, 2013 ? Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found a compound that could counter Parkinson's disease in two ways at once.
In a new study published recently online ahead of print by the journal ACS Chemical Biology, the scientists describe a "dual inhibitor" -- two compounds in a single molecule -- that attacks a pair of proteins closely associated with development of Parkinson's disease.
"In general, these two enzymes amplify the effect of each other," said team leader Phil LoGrasso, a TSRI professor who has been a pioneer in the development of JNK inhibitors for the treatment of neurodegenerative diseases. "What we were looking for is a high-affinity, high-selectivity treatment that is additive or synergistic in its effect -- a one-two punch."
That could be what they found.
This new dual inhibitor attacks two enzymes -- the leucine-rich repeat kinase 2 (LRRK2) and the c-jun-N-terminal kinase (JNK) -- pronounced "junk." Genetic testing of several thousand Parkinson's patients has shown that mutations in the LRRK2 gene increase the risk of Parkinson's disease, while JNK has been shown to play an important role in neuron (nerve cell) survival in a range of neurodegenerative diseases. As such, they have become highly viable targets for drugs to treat disorders such as Parkinson's disease.
A dual inhibitor ultimately would be preferred over separate individual JNK and LRRK2 inhibitors because a combination molecule would eliminate complications of drug-drug interactions and the need to optimize individual inhibitor doses for efficacy, the study noted.
Now the team's new dual inhibitor will need to be optimized for potency, high selectivity (which reduces off-target side effects) and bioavailability so it can be tested in animal models of Parkinson's disease.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/p7Umt7hwgkQ/130620111138.htm
stephen jackson marchmadness mike d antoni nba trade rumors desean jackson 2012 ncaa tournament schedule laurent robinson
Sunday, June 9, 2013
Google: There Is No PRISM Back Door To Our Servers, No Open-Ended Access To User Data
All of the companies that are allegedly involved in the PRISM surveillance program have now issued short statements saying that they are not participating in this program and that they are not allowing the government "direct access" to their servers. Among these, of course, is Google. The company, however, also just issued a longer statement penned by its CEO Larry Page and Chief Legal Officer David Drummond.Source: http://feedproxy.google.com/~r/Techcrunch/~3/CS7hBbj4VsE/
sweet potato casserole Pumpkin Pie Recipe wii u wii u American Music Awards turkey brine Imessage Not Working
Alt-week 6.8.13: the Tetris printer, micro-vacuums and naked Antarctica
Alt-week takes a look at the best science and alternative tech stories from the last seven days.
Printing can take many forms these days, it seems. It's a term we see pulled in another direction this week, but one we think you'll enjoy. Want something a little more tangible? How about advanced Antarctic topology, or gas-detecting microscale vacuum pumps? Yep, this is alt-week.
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ctO6G_v98lI/
gucci mane Chicago sinkhole Panda Express illuminati illuminati ricin Google Fiber
Saturday, June 8, 2013
Japanese Porsche Fan Commissions the World's Most Elegant Garage
The Porsche 911 is a thing of beauty: Designed in 1959 by "Butzi" Porsche himself, its clean lines and German engineered guts have turned it into a much-obsessed-over classic. To wit: this Osaka townhome designed by Kenji Yanagawa Architects, for a client with an unusual request?that the entire structure be oriented around the garage. The garage, you see, holds his classic silver 911.
     |
dallas tornado video 1940 census instagram for android dallas news dallas fort worth dfw 1930 census
Friday, June 7, 2013
CEO Talk | Scott Malkin, Chairman, Value Retail - The Business of ...
BICESTER, United Kingdom ? The ultimate metric for retail performance is sales density, typically measured in sales per square foot. Indeed, for a chief executive managing a retail business, regular growth in sales density is the holy grail.
Apple stores, widely considered to have the highest sales density in the world, clock in at about $6,000 per square foot. In the luxury sector, where rents are high and store fit-outs are extremely expensive, a store with a sales density of over $2,000 per square foot is considered to be very high performing.
No wonder, then, that Scott Malkin, chairman of Value Retail, parent company of nine discount shopping centres dotted around Europe, is ebullient. On the day I meet him in Bicester Village ? a luxury shopper?s paradise with past-season merchandise from some of the most prestigious fashion brands in the world including Prada, C?line, Dior, Burberry, Ralph Lauren and Alexander McQueen at heavily discounted prices ? about one hour outside London, the outdoor mall is teeming with shoppers and the parking area is jampacked. According to statistics supplied by Value Retail and the International Council of Shopping Centres (ICSC), with an average sales density of $3,309 per square foot, Bicester Village was by far the most productive shopping centre in the world in 2012, outstripping Bal Harbor Shops in Miami (at $2,555 by per square foot) by about 30 percent.
Indeed, although they might prefer for it to remain a secret, Bicester Village is very often the number one sales outlet in the world for many of Malkin?s brand partners. In 2012, this earned Value Retail more than 1.7 billion euros in revenue, which has tripled over the past 5 years.
So, what?s the secret to Value Retail?s success?
It all comes down to incentives. Rather than taking a monthly rent from his tenants, Malkin earns a royalty on sales, perfectly aligning the goals of tenant and landlord to constantly improve sales density and other key performance metrics. As such, Value Retail is actively involved in promoting, managing and optimising the retail experience for the millions of global shoppers that descend on Europe each year.
BoF took a tour of Bicester Village and then sat down with Scott Malkin to learn more about his operating strategy and the business of building Value Retail.
BoF: The first thing that I want to discuss is how the business works. It?s not a pure real estate business, per se. Can you talk about how Value Retail makes money?
SM: It?s a hybrid of real estate and retail. We don?t ?build and fill and sell,? [which is more like] a manufacturing real estate business. Really, there is no real estate income. [There?s] a marketing fee, some service charges, [and] maintenance charges. Essentially, the structure is: we have licensing arrangements with brands who take the space and pay a royalty.
BoF: Like a shop-in-shop type business?
SM: Yes. Structurally, we are more akin to a Harrods or a Selfridges than US department stores [which] buy the stock. We also work with brands in terms of visual merchandising and direction on staff training. The brands are thinking about the next challenge, the next issue, the next new store opening ? and all the way at the back is surplus stock and the mechanisms for dealing with it.
And yet, what one finds in these villages is that fashion editors are here all the time shopping for husbands and children. These are not unsophisticated buyers. So how do you create a place that is an alternative to full price in its pure form, but supportable for full price by identifying and serving aspirational customers?
BoF: So, if I understand correctly, in exchange for this royalty, your brand partners are not just getting space, they are getting a service. What service does Value Retail as a company provide to a brand opening a store here?
SM: What we?re doing is saying in every step of the process: ?Here?s what we understand to be best practice for our village in this market.? But the relationship is delicate because highly creative and intense organizations, which is what a good brand is, don?t necessarily want unfamiliar inputs or interference. It?s good if the feedback comes from people who are retailers, who speak that language, know a product, who can?t be shunted aside. But on the other hand brands will say, and have said, you guys are incredibly demanding and it helps us a lot, but it?s frustrating.
BoF: So could you bring that to life a little?
SM: Hiring, training, it?s always that tug of war. We can make certain arguments that they?ll listen to. But as examples, most of the brands who came here from Italy are in their third shop fit. They would argue for concrete floors and we would say ?no, sorry? we won?t approve those. They would stick up orange signs. The whole idea mentally was: ?This is a dumping ground.?
Discount in the way Europeans think about it ? it?s dumping. [They see discount as] just another way of jobbing stock, which says we don?t really have regard for the customer. The shopper can tell the difference.
So the woman who will spend ?5,000 for a piece of fur that used to be ?10,000 ? and it happens multiple times each week ? and the one who will pay ?200 for a pair of shoes that used to be ?400 ? that?s is a rare creature. The average price for a pair of shoes in the UK is something like ?14.
If she?s gone halfway across the world to do it. And by the way, if she has a driver in the car, waiting for the day for her, anything she is saving in price is going towards petrol, the chauffeur, the car from the hotel, her act of coming here is not about discount in anyway. Nobody spends ?200 for anything thinking ?discount.?
BoF: Bicester Village did more than $3,000 a square foot in sales last year. How do you explain this really high sales density?
We rate each brand?s [performance] and give them feedback on identity, merchandise mix and sales densities, which is another measurement of brand relevance to the customer and brand contribution in terms of royalty income.
When a brand opens we present them with a series of touchpoints, which hopefully will add value quickly. It?s a partnership, it truly is. We are legitimately able to talk to the brand for three reasons: one, we are retailers; two, we are sharing their success and their risk; and three, we are investing hugely in global and tourism marketing. We?ve been doing that for ten years, and are starting to see the benefits of it today. Three or four years ago, eight percent of our visitation for our villages across Europe was from non-EU shoppers. Last year was 25 percent non-EU shoppers.
BoF: But you are not planning to build more villages to capture more of this tourist shopper opportunity.
We don?t need to build more villages [in Europe], we need to drive the performance of the villages we have. Should Bicester Village outside of London and Le Vall?e Village outside of Paris have different sales density per square foot, given the size of the catchment, the volume of inbound tourism, the quality of brands at full price that therefore have surplus stock? No, they should be the same. But Bicester Village [has been] growing double digits for 17 years. Year-to-date we are up 16 percent, like-for-like, and Paris can?t keep up. It should do and will do at some point. It just creates an upside in the operating business, since we?re on a royalty, that?s how I can create new villages, by improving the operating performance. Improving the value I deliver to our customers, the brands, and improving the experience for the shopper.
It?s [about the] magnetic appeal of the hospitality experience. If you think about long-distance resort hotel experiences, there?s a lot of that. The greeting, the room, the linen, the bedding, it?s broadly consistent, yet some places absolute sparkle ? and that?s the artistry [of retail] and that?s what we?re very much focused on. If we don?t constantly reinvent ourselves, we?re not keeping up with our brands.
BoF: As we were walking through Bicester Village just now, the presence of the Chinese shopper was clear. Can you give me a profile of the typical Value Retail Chinese consumer?
The Chinese consumer is moving faster than anything I?ve ever seen. The rate of maturing, the rate of growing sophistication is incredibly impressive and they?re in that moment of epiphany [when they] determine that a heavily logo-ed bag is a secretary?s bag. I?m not even sure Japan is there yet, but they?ve been inching towards that. Russia?s not there yet, Brazil?s not there yet. China got there seemingly overnight, very, very quickly.
The Chinese consumer, today, is noticeably different even from last year. Now, they are coming with a driver and car, not on a coach tour, maybe with a child who?s been educated in Canada or the US or Britain, speaking English. That consumer is fundamentally aspirational, has spending power up to a point, and has an absolute fixation on authenticity. These people say ?we bought them here because we want the real thing, we believe these are authentic and if we buy them in China we?ll never know if they are counterfeit.?
BoF: And, how does that link to your strategy for opening in China early next year in Suzhou for Spring 2014?
We?ll be spending $100 million in seven years. Our next project is Shanghai Disney. If all goes well, a woman will show up, she?ll walk around for half an hour, and she?ll then say ?I?ve been to Europe, this is the real thing, this is great.?
Even if my people are working on China, they are reminded everyday that the shopper we receive is global. We, as a business, are global and they need to think about participating in the global economy.
These are talented, capable people who have choices and elect to work with us because there is an environment, a mission, a product they are satisfied with, that they believe in, not because they need a job, which is why it?s so much fun for me, and for them, to work at Value Retail.
This interview has been edited and condensed.
Source: http://www.businessoffashion.com/2013/06/ceo-talk-scott-malkin-chairman-value-retail.html
king arthur there will be blood there will be blood nigel barker secret service fenway park philadelphia flyers
'Toddlers & Tiaras' dad slams 'fat' moms
TV 
20 hours ago
It's time for a new season of "Toddlers & Tiaras," which means it's also time for some new controversy.
The TLC reality series never lacks scenes that get people talking. In seasons past, questionable costumes, moms behaving badly and at least one cigarette-toting tot vied for viewer outrage. But this time around, it looks like there's a pageant dad who wants in on the action.
In a clip TLC provided exclusively to TODAY.com, JD, father of pageant princess Brooke, gives his take on the "huge" moms he sees all around him at his daughter's events.
"I don't like judging people by any means," JD says before before doing that very thing. "But you just see a lot of people ? man, they just barely fit in their clothes. I mean, I'm seeing women walk around, frickin' love handles sticking out their shirt."
Mean? Sure, but JD, whose bulging biceps prove his love of fitness, feels that the women are judging him too.
"I'm just thinking, 'Man, you know they're staring at me, judging me,'" he explains as a scene shows him doing pushups stage-side while decked out in a shimmer shirt and oversized afro wig. "It's like, 'What are you teaching your daughter when you're walking around huge like that and out of shape?'"
Finally, while on a roll, JD flexes his massive, veiny muscles and announces, "This is for all the fat pageant moms that are overweight, eating cupcakes."
OK then. Team Cupcakes.
The new season of "Toddlers & Tiaras" kicks off Wednesday at 9 p.m. on TLC.
Source: http://www.today.com/entertainment/pageant-dad-slams-fat-moms-toddlers-tiaras-premiere-6C10193795
tom benson royals nicole richie lyme disease symptoms esperanza spalding jessica sanchez robert kennedy
Subscribe to:
Comments (Atom)